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Silverline Research is committed to optimizing human performance and brain plasticity by providing state-of-the-art and innovative neurotechnology research & development solutions in integrated brain stimulation and imaging technologies
Non-Invasive & Integrated Solutions...
Silverline Research has accumulated over 15years of academic and research expertise in electrical brain stimulation technologies (tES, rTMS, DBS, NMES) and successfully developed integrated solutions combining these electrical stimulation techniques with non-invasive neuroimaging (fNIRS, fMRI) and electrophysiological (TMS, EEG) techniques.
This extensive knowledge base in brain stimulation and imaging technologies enables Silverline Research to provide state-of-the-art and innovative research support solutions in a wide range of research and clinical applications.
OptEStim: Optimized transcranial Electrical Stimulation Software Platform for closed-loop tES-EEG-fNIRS
As transcranial electrical stimulation (tES: tDCS, tACS, tRNS) research and technology evolve, methods to optimise tES protocols are necessary to personalise and enhance the effects of neuromodulation. Open-loop tES protocols apply standard tES parameters (current amplitude, frequency and duration) for one-size fits all; while closed-loop tES protocols allow individual brain-state dynamics to modify ongoing tES parameters.
Brain-state neurovascular dynamics during and after tES neuromodulation can be measured non-invasively using fNIRS (hemodynamics) and EEG (neuronal activity) imaging methods.
OptEStim is a cross-platform software application developed by Silverline Research that provides advanced level brain-state neurovascular dynamics determination using joint EEG-fNIRS imaging, and provides open-loop and closed-loop programs to test different tES-fNIRS/EEG experimental protocols.
OptEStim is currently configured with the Starstim fNIRS system. Requests for demonstration of the OptEStim software with the Starstim fNIRS system are provided by our partner Artinis Medical Systems
OptEStim closed-loop software platform details:
OptEStim is a cross-platform that offers advanced software-level capabilities for real-time monitoring and analysis of EEG and fNIRS metrics (e.g. EEG-Alpha peak and fNIRS-O2Hbmean), including novel heart rate (HR) and variability (HRV) metrics extracted from fNIRS signals.
An original feature of the OptEStim platform is the ability to define different open-loop (i.e., standard tES protocols) and closed-loop (Entrainment and Conditional programs included) programs to test experiments using the tES parameters (tDCS, tACS, tRNS) using EEG and/or fNIRS metrics to close the loop.
The Entrainment closed-loop program allows the user to define the EEG metric (e.g., initial Alpha peak power) to close the loop; while the Conditional closed-loop program allows both EEG (e.g., Alpha COG, Gamma peak power) and fNIRS (Mean O2Hb, HHb, HR, HRV) metrics to set the threshold for tES.
OptEStim software (Beta) provides:
Synchronous tracking of brain activity (EEG) and hemodynamics (fNIRS)
instant visualizations of EEG-fNIRS analytics
Open-loop, Entrainment and Conditional closed-loop programs
Results of session as raw and detailed EEG and fNIRS analytics of all channels are provided in csv format
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