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A Foundation of Expertise
A Foundation of Expertise
Silverline Research develops advanced software platforms and cutting-edge training solutions that integrate neuroimaging and neurostimulation technologies for academic and clinical laboratories.
Our foundation is built on over 15 years of rigorous research and development led by our founder, Dr. Mark Muthalib. Since 2007, his research legacy has spanned leading institutions across Australia, the UK, Europe, and the USA.
(Link: Explore the research publications detailing multimodal neuroimaging and non-invasive brain stimulation here.)
Collaborative R&D and Strategic Partnerships
Collaborative R&D and Strategic Partnerships
We accelerate our trajectory of continuous innovation by synergizing our in-house R&D with strategic academic and industry partnerships.
By collaborating with premier neurotechnology hardware leaders for fNIRS systems (including Artinis Medical Systems and Train.Red), as well as EEG and brain stimulation systems (such as Neuroelectrics and BrainPatch), we are able to dedicate our resources directly toward advancing our core integrated multimodal software platforms.
Today, our collaborative projects actively push the boundaries of non-invasive, real-time human measurement and closed-loop neuromodulation.
(Link: Discover more about these initiatives and our clinical validations on our Projects webpage.)
Neuroelectrics Webinar
Neuroelectrics Webinar
Why combine Neuroimaging with Neurostimulation in research and clinical applications presented by Dr. Muthalib
Pioneering Active Brain Recovery
Pioneering Active Brain Recovery
Building upon our established research platforms (OptEStim and MyndSens Pro), Silverline Research is engineering a proprietary closed-loop ecosystem designed to actively combat mental fatigue and accelerate cognitive recovery.
MyndSens® Software: This is our proprietary mobile application designed to capture a comprehensive, real-time picture of cerebral haemodynamics and the user's autonomic state. The platform's capabilities were demonstrated and validated in a high-intensity, hackathon-like environment by leading neurotechnology experts at N-CODE 2024. Currently in beta, the MyndSens app pairs with guided breathwork protocols to seamlessly track and record cerebrovascular and autonomic rhythms.
(Link: Read the N-CODE 2024 validation report here)
MyndSwitch® Interface is our advanced prototype wearable interface which is designed to measure cerebral haemodynamics using advanced fNIRS sensors while delivering precise Closed-Loop Auditory Stimulation (CLAS). MyndSwitch moves far beyond passive monitoring; it dynamically optimizes brain states through phase-locked neuromodulation to execute personalized rest activities. Uniquely, the MyndSwitch ecosystem is designed to optimize the physiological states associated with restorative neural processes by guiding the brain into the exact rhythms required for deep, physical recovery.
(The MyndSwitch® platform is currently intended for research and wellness applications. It is not intended to diagnose, treat, or cure any medical condition.)
MyndSens ®
MyndSens ®
Breathwork session with real-time fNIRS tracking of cerebral vasomotion
Scientific Advisers:
Scientific Advisers:
Silverline Research maintains strong R&D collaborations and scientific advisory support with leading neuroscience academics and laboratories that continue to develop new knowledge to advance a better understanding of human brain functioning and performance.
EuroMov Centre, The University of Montpellier, France,
Institute of Neurology, University College London, UK,
Department of Metabolism and Systems Science, University of Birmingham, UK
Lancashire Teaching Hospitals NHS Foundation Trust and University of Lancashire, UK
Relevant peer-reviewed publications:
Relevant peer-reviewed publications:
The full detailed list of publications integrating neurostimulation (tDCS, tACS, tRNS, TMS, DBS) with neuroimaging (fNIRS, EEG, fMRI) can be found at the Researchgate repository
Neurophysiological Correlates of tDCS-Induced Modulation of Cortical Sensorimotor Networks: A Simultaneous fNIRS–EEG Study. Muthalib M, Besson P, Dutta A, Hayashibe M, Perrey S. Neuroergonomics The Brain at Work and in Everyday Life 2019, Pages 147-151 DOI: 10.1016/B978-0-12-811926-6.00024-5
Focal Hemodynamic Responses in the Stimulated Hemisphere During High-Definition Transcranial Direct Current Stimulation. Muthalib M, Besson P, Rothwell J, Perrey S. Neuromodulation 2018, 21(4): DOI: 10.1111/ner.12632
Does a Combination of Virtual Reality, Neuromodulation and Neuroimaging Provide a Comprehensive Platform for Neurorehabilitation? – A Narrative Review of the Literature. Teo WP, Muthalib M, Yamin S, Hendy AM, Bramstedt K, Kotsopoulos E, Perrey S, Ayaz H. Frontiers in Human Neuroscience 2016, 10(871): DOI: 10.3389/fnhum.2016.00284
Grey-box linear modeling to analyze functional near-infrared spectroscopy-based cerebrovascular reactivity to anodal HD-tDCS in healthy humans. Arora Y, Walia P, Hayashibe M, Muthalib M, Chowdhury SR, Perrey S, Dutta A. Pre-print. DOI. 10.21203/rs.3.rs-83907/v3
Concurrent anodal transcranial direct-current stimulation and motor task to influence sensorimotor cortex activation. Besson P, Muthalib M, Dray G, Rothwell J, Perrey S. Brain Research. 2019, 1710:181-187 DOI: 10.1016/j.brainres.2019.01.003
High-definition transcranial direct-current stimulation of the right M1 further facilitates left M1 excitability during crossed-facilitation. Cabibel V, Muthalib M, Teo WP, Perrey S. Journal of Neurophysiology 2018, 119(4) DOI: 10.1152/jn.00861.2017
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