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Silverline Research
Silverline Research is a neurotechnology consultancy committed to optimising human performance and research outcomes.
Trusted Expertise
With over 15 years of academic and operational experience, Silverline provides state-of-the-art training, system integration, and R&D consultancy across electrical brain stimulation (tES, rTMS, DBS) and non-invasive neuroimaging (fNIRS, EEG). We are a trusted partner to neurotechnology manufacturers, as well as academic, clinical, and corporate research labs worldwide.
R&D Platforms & Training
We bridge the gap between hardware and research through our proprietary integration tools:
OptEStim Platform – our flagship training and experimentation environment for designing and testing closed-loop brain stimulation protocols using both EEG and fNIRS.
MyndSens Pro – a multi-sensor streaming and recording suite that integrates with any Lab Streaming Layer (LSL) compatible device, enabling synchronised acquisition across complex neurotechnology setups.
Innovation
Building on this technical foundation, we are advancing next-generation digital wellness technologies. Moving beyond simple tracking, we develop AI-enabled tools that identify and amplify the brain’s natural restorative rhythms, supporting cognitive recovery and performance in high-demand environments.
Our Mission
Whether empowering researchers with robust lab solutions or pioneering new methods for Active Neuro-Restoration, Silverline is dedicated to pushing the boundaries of human performance and recovery.
OptEStim Software Platform for EEG-fNIRS real-time analysis and closed-loop stimulation
As transcranial electrical stimulation (tES: tDCS, tACS, tRNS) research and technology evolve, methods to optimise tES protocols are necessary to personalise and enhance the effects of neuromodulation. Open-loop tES protocols apply standard tES parameters (current amplitude, frequency and duration) for one-size fits all; while closed-loop tES protocols allow individual brain-state dynamics to modify ongoing tES parameters.
Brain-state neurovascular dynamics during and after tES neuromodulation can be measured non-invasively using fNIRS (hemodynamics) and EEG (neuronal activity) imaging methods.
OptEStim is a cross-platform software application developed by Silverline Research that provides advanced level brain-state neurovascular dynamics determination using joint EEG-fNIRS imaging, and provides open-loop and closed-loop programs to test different tES-fNIRS/EEG experimental protocols.
OptEStim is currently configured with the Starstim fNIRS system. Requests for demonstration of the OptEStim software with the Starstim fNIRS system are provided by our partner Artinis Medical Systems
OptEStim Software Platform details:
OptEStim Software Platform offers advanced software-level capabilities for real-time monitoring and analysis of EEG and fNIRS metrics (e.g. EEG-Alpha peak and fNIRS-O2Hbmean), including novel heart rate (HR) and variability (HRV) metrics extracted from fNIRS signals.
OptEStim also is the first to provide built-in EEG-fNIRS closed-loop tES programs. This original feature of the OptEStim platform alloows the user to define different open-loop (i.e., standard tES protocols) and closed-loop (Entrainment and Conditional programs included) programs to test and run research experiments using the tES parameters (tDCS, tACS, tRNS) using EEG and/or fNIRS metrics to close the loop.
The Entrainment closed-loop program allows the user to define the EEG metric (e.g., initial Alpha peak power) to close the loop; while the Conditional closed-loop program allows both EEG (e.g., Alpha COG, Gamma peak power) and fNIRS (Mean O2Hb, HHb, HR, HRV) metrics to set the threshold for tES.
OptEStim software (Beta) provides:
Synchronous tracking of brain activity (EEG) and hemodynamics (fNIRS)
instant visualizations of EEG-fNIRS analytics
Open-loop, Entrainment and Conditional closed-loop programs
Results of session as raw and detailed EEG and fNIRS analytics of all channels are provided in csv format
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